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Introduction to Computational Sequence Analysis

The CNIO Bioinformatics Unit organises an introductory course on computational sequence analysis, to be held on Wednesday, July 16th 2008, at the CNIO Seminars Room, 3rd floor.

Over the last ten years the amount of biological sequence data available to researchers has increased by several orders of magnitude, and complete genome sequences (nearly nonexistent ten years ago) have become commonplace. Some techniques involved in analyzing nucleotide and amino acid sequences (e.g. BLAST) have become so commonly used in molecular biology that their names have become verbs. This introductory course is aimed at biologists with little or no previous experience, but also at those users who wish to know more about the methods underlying computational sequence analysis tools.

The course is limited to 15 persons. Laptop computers will be provided to the attendants. Please contact us (This email address is being protected from spambots. You need JavaScript enabled to view it. ) in advance if you wish to attend the course.

  • Teacher: Osvaldo Graña, Bioinformatics Unit (CNIO) 

Course Agenda

1. Nucleotide Analysis

  • 9:00 Introduction
  • 9:30 Checking for Vector Contamination -  A hands-on introductory example
  • 10:00 Searching for Similarity
  • 11:00 Coffee break
  • 11:20 Whole Genome Searches
  • 11:45 Pairwise Alignment Methods
  • 12:15 Multiple Sequence Alignment Approaches
  • 12:45 Translating DNA/RNA into Protein

2. Protein and Proteomic Analysis

  • 13:00 Introduction
  • 13:20 Similarity Search for AA Sequences
  • 14:30 Lunch
  • 16:15 Similarity Search for AA Sequences (cont.)
  • 16:45 Whole Proteome Searches
  • 17:15 Multiple Sequence Alignment with Proteins
  • 17:45 Coffee Break
  • 18:00 Proteomics example with InterProScan
  • 18:15 CNIO Tools: Searching with Decypher
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